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However, the report also found conclusive evidence that completely substituting e-cigarettes for combustible tobacco cigarettes reduces users exposure to numerous toxicants and carcinogens present in combustible tobacco cigarettes. In terms of nicotine intake, the report uncovers substantial evidence that nicotine exposure from e-cigarettes among experienced adult e-cigarette users can be comparable to that from combustible tobacco cigarettes. There is also substantial evidence that heart rate increases after nicotine intake from e-cigarettes, and that some chemicals present in e-cigarette aerosols (e.g., formaldehyde, acrolein) are capable of causing DNA damage and mutagenesis. This is important because we can plausibly infer from this that long-term use of e-cigarettes could raise the risk of cancer, write the authors of the report